Prevalence of glucose-6-phosphate dehydrogenase (G6PD) deficiency in malaria endemic region of Iran (Sistan and Baluchestan Province): Epidemiological profile and trends over time
نویسندگان
چکیده
*Corresponding author: Hossein Ali Adineh, Department of Epidemiology and Biostatistics, Iranshahr University of Medical Sciences, Iranshahr, Iran; Health Promotion Research Center, Zahedan University of Medical Sciences, Zahedan, Iran. Tels: +98 9156388799, +98 5437222230 E-mail: [email protected] This study protocol was performed according to the Helsinki Declaration and was assessed for ethic issues and approved by Ethical Committee of Zahedan University of Medical Sciences, Iran. Written informed consent was obtained from the heads of households. Foundation Project: Supported by World Health Organization (EMRO/TDR Small Grant with ID No. SGS 14/20), Deputies of Health and Research and Health Promotion Research Center in Zahedan University of Medical Sciences. The journal implements double-blind peer review practiced by specially invited international editorial board members.
منابع مشابه
Prevalence of Glucose-6-phosphate Dehydrogenase (G6PD) Deficiency in Patients Suspected of Favism in Qaleh Ganj, Southern Iran: A Restriction for Malaria Elimination
Background and purpose: Despite wide fight against malaria in endemic regions, it is still one of the most serious infectious diseases in some parts of the world. Primakin is effective in treatment and prevention of malaria. However, individuals with glucose-6-phosphate dehydrogenase (G6PD) deficiency are at risk for hemolysis and its complications when taking primakin. This study was performe...
متن کاملPrevalence of glucose-6-phosphate dehydrogenase (G6PD) deficiency in southeast Iran: implications for malaria elimination.
INTRODUCTION Glucose-6-phosphate dehydrogenase deficiency (G6PD) is an X-linked genetic disorder with a relatively high frequency in malaria-endemic regions. It is an obstacle to malaria elimination, as primaquine administered in the treatment of malaria can cause hemolysis in G6PD-deficient individuals. This study presents information on the prevalence of G6PD deficiency in Sistan and Balouche...
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Glucose-6-phosphate dehydrogenase (G6PD) in humans is an X-chromosome-linked disorder and housekeeping enzyme, vital for the survival of every cell. It catalyses the oxidation of glucose-6-phosphate to 6-phospho gluconate in the first committed step of the pentose phosphate pathway, which provides cells with pentoses and reducing power in the form of NADPH. NADPH is required to protect the cell...
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Glucose-6-phosphate dehydrogenase (G6PD) deficiency is an enzymopathy affecting about 400 millionpeople worldwide. The distribution of G6PD deficiency and the molecular genetics of this enzyme vary widelyamong different ethnic groups. The aim of this study was to find out the frequency of G6PD deficiency andcharacterize the Mediterranean type mutation in deficient individuals ...
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BACKGROUND This study aimed to evaluate the prevalence and alteration of hematological parameters in malaria patients with a glucose-6-phosphate dehydrogenase (G6PD) deficiency, in the western region of Thailand, an endemic region for malaria. METHODS Data about patients with malaria hospitalized between 2013 and 2015 were collected. Clinical and sociodemographic characteristics such as age a...
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